basic FUNCTION
| structural protein with modified conformation when calcium is removed |
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playing with MATN3 an important role in matrix assembly |
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may function to stabilize the articular cartilage extracellular matrix by specific cation-dependent interactions with matrix components, including collagen types II and IX, fibronectin, aggrecan, and matrilin-1, -3, and -4 |
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may act as the co-factor of the GRN cell surface receptor and may present GRN to its receptor, followed by the activations of GRN-mediated signal transduction and gene regulation pathways |
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playing a role in catalyzing the assembly of collagen, promoting formation of well defined fibrils |
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promotes cell attachment via two independent mechanisms involving cell surface CD47 and alphaVbeta3 integrin (and consequence of cell attachment to COMP is the specific induction of fascin-stabilized actin microspikes) (Rock 2010) |
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pivotal for maintaining the homeostasis of vascular smooth muscle cells (VSMCs) |
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potential novel inhibitor of vascular calcificationand the imbalance between the effects of COMP and BMP2 may provide new insights into the pathophysiology of vascular calcification |
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functions as an adapter protein in human skin, similar to its function in cartilage ECM, by organizing collagen I fibrils into a suprastructure, mainly in the vicinity of anchoring plaques that stabilize the cohesion between the upper dermis and the basement membrane zone |