Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GPR182 contributors: npt - updated : 07-05-2004
HGNC name G protein-coupled receptor 182
HGNC id 13708
Location 12q13.3-q14      Physical location : 57.388.354 - 57.390.468
Synonym name adrenomedullin receptor
Synonym symbol(s) HRHAMR, AMR, 7TMR, ADMR
DNA
TYPE functioning gene
STRUCTURE 2.00 kb     2 Exon(s)
regulatory sequence Binding site   HRE
text structure several SP1,AP2,CAAT sites as well as hypoxia-responsive elements (HRE)
MAPPING cloned Y linked N status provisional
Map cen - D12S1691 - GPR182 - CENTG1 - D12S355 - qter
Authors GeneMap (98)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1620 45 404 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Cardiovascularheart   highly
Digestiveliver    
 stomach    
Endocrineadrenal gland    
 pancreas    
 thyroid    
Lymphoid/Immunelymph node    
Nervousbrainhindbrainmedulla oblongata  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Respiratoryepithelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two potential glycosylation sites in the N terminal region
  • several serine and threonine cytoplasmic phosphorylation sites
  • HOMOLOGY
    Homologene
    FAMILY
  • adrenomedullin peptide family, members of CGRP
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • having rhodopsin-like receptor activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • potential ligand : calcitonin gene related peptide,
  • amylin, adrenomedullin peptide family
    cell & other
    REGULATION
    induced by hypoxia
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS