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FLASH GENE
Symbol GZMM contributors: mct/ - updated : 07-01-2006
HGNC name granzyme M (lymphocyte met-ase 1)
HGNC id 4712
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a trypsin domain
  • peptidase S1 domain
    • HOMOLOGY
    interspecies homolog to murine Gzmm
    Homologene
    FAMILY
  • peptidase S1 family
  • granzyme subfamily
    • CATEGORY enzyme , immunity/defense
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • granule serine protease, cleaving after methionine (Met-ase)
  • involved in major and specialized perforin-dependent cell death pathway that plays a significant role in death mediated by NK cells
  • chymotrypsin-like serine protease that preferentially cuts its substrates after Met or Leu
  • may play an important role in innate immunity
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physiological substrate for BIRC5 (hydrolyzes Survivin at Leu-138 to remove the last four C-terminal residues)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS