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FLASH GENE

Symbol

GZMM

contributors: mct/ - updated : 07-01-2006

HGNC name	granzyme M (lymphocyte met-ase 1)
HGNC id	4712

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.3      Physical location : 544.026 - 549.919
Genatlas name	L36922, L36936,
Synonym name	natural killer cell granular protease
	lymphocyte met-ase 1
Synonym symbol(s)	HUMET, NKPS, MET1, LMET1, Hu-Met-1
EC.number	3.4.21.-

DNA

TYPE	functioning gene
STRUCTURE	5.89 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005317 5 - 947 NP_005308 - 257 - -

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune thymus

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune activated B lymphocyte Lymphoid/Immune natural killer Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a trypsin domain
	peptidase S1 domain

HOMOLOGY

interspecies

homolog to murine Gzmm

Homologene

FAMILY	peptidase S1 family
	granzyme subfamily

CATEGORY

enzyme , immunity/defense

SUBCELLULAR LOCALIZATION

basic FUNCTION	granule serine protease, cleaving after methionine (Met-ase)
	involved in major and specialized perforin-dependent cell death pathway that plays a significant role in death mediated by NK cells
	chymotrypsin-like serine protease that preferentially cuts its substrates after Met or Leu
	may play an important role in innate immunity

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

physiological substrate for BIRC5 (hydrolyzes Survivin at Leu-138 to remove the last four C-terminal residues)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS