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FLASH GENE

Symbol

NFATC1

contributors: mct/pgu - updated : 04-08-2018

HGNC name	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
HGNC id	7775

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism other	SNP rs2887571 is a binding site for ESR1 and NFATC1 and they regulate the expression of WNT5B

Candidate gene	potential VSD-susceptibility gene
Marker
Therapy target
	System Type Disorder Pubmed neuromuscular myopathy   FHL1-NFATC1-UTRN signaling axis that can functionally compensate for dystrophin and treat DMD immunology autoimmune   targeting NFATC1 SUMOylation presents a novel and promising strategy to treat T cell-mediated inflammatory diseases cancer lung   critical participant in antitumor immune responses in patients with NSCLC

ANIMAL & CELL MODELS

mice with NFATc1-deficient T cells are defective in controlling Listeria infection