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FLASH GENE

Symbol

LCK

contributors: mct/pgu - updated : 16-02-2016

HGNC name	lymphocyte-specific protein tyrosine kinase
HGNC id	6524

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

IMD22

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   translocation     breakpoint in T-cell acute lymphoblastic leukemia with translocations t(1;7)(p34;q34 constitutional     --low   in one case of SCID(severe combined immunodeficiency) tumoral     --over   in lymphomas of germinal center origin (e.g. follicular lymphoma) and also many mantle cell lymphomas, chronic lymphocytic leukemia (CLL) and most T-cell neoplasms

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer hemopathy   small-molecule inhibitors of Lck, such as dasatinib, may function to reverse glucocorticoid resistance in some lymphoid malignancies

ANIMAL & CELL MODELS