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FLASH GENE

Symbol

ALDH1A3

contributors: mct - updated : 25-02-2011

HGNC name	aldehyde dehydrogenase 1 family, member A3
HGNC id	409

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MCOP8

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in non small cell lung cancer (Moreb 2008) constitutional     --over   deregulates the balanced mechanisms of insulin and glucagon secretion in the pancreatic islets and may induce beta-cell dysfunction leading to the development of type 2 diabetes constitutional       loss of function causes anophthalmia and aberrant eye development

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	novel cancer stem cells marker with potential clinical prognostic applicability (clear correlation between cancer stem cells prevalence and the development of metastatic breast cancer)
Therapy target

ANIMAL & CELL MODELS

Aldh1a3-/- mutant mice embryos begin the process of optic cup formation, but they exhibit ventral retina shortening associated with lens rotation and persistence of primary vitreous