protein
| steroidogenic factor 1, SF-1 |
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heat shock 70 kDa, HSP70 |
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thyroid hormone receptor-associated protein complex 230 kDa component, TRAP230 |
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c-Maf transcription factor, Lc-Maf |
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cAMP-response element-binding protein (CREB)-binding protein (CBP)/p300 |
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SMAD family member 2, Smad2 and SMAD family member 3, Smad3 |
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nucleocytoplasmic transport protein importin beta, IPOB |
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with HSPA1A in chondrocytes and testicular cell lines |
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binding as a monomer to the regulatory region of sex-determining factor NR5A1 |
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interaction with NFATC1 for endocardial cushion formation |
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interacts with chromatin and activates transcription via regulation of chromatin modification |
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interacting with WNT4 and CTNNB1 (antagonism between SOX9 and CTNNB1 potentially is the molecular mechanism through which the fate of the supporting cell lineage in the gonad is established to drive male or female sex determination) |
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first direct target of CEACAM1 identified in the colon epithelium (SOX9 upregulates CEACAM1 in colonic cells) |
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cAMP responsive element binding protein 1, CREB1 |
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interacting with SOX8 (concerted SOX9 and SOX8 function in Sertoli cells is essential for the maintenance of testicular function) |
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scleraxis, Scx and E47 |
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interaction with DMRT1 appear to have swapped roles in the regulatory hierarchy of the vertebrate testis |
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binds to the location around the paired SOX site in the BEST1 promoter in RPE cells ( |
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SHOX cooperates with SOX5/SOX6 and SOX9 in the activation of the upstream ACAN enhancer( |
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SOX9 activates TES, augmented by NR5A1, suggesting a mechanism for maintenance of SOX9 expression by auto-regulation |
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regulatory interaction between SOX9, WWP2 and MED25 defines the SOX9 transcriptional mechanisms of chondrogenesis in the forming palate ( |
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AT rich interactive domain 5A (MRF1-like), ARID5A |
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BMP signal pathway and SOX9 are required for the onset of chondrogenesis, suggesting that BMP4 and SOX9 are candidate regulators of phenotypic change of mesangial cells in the advanced stage of diabetic nephropathy |
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DMRT1 maintains SOX9 and suppresses FOXL2 expression in postnatal Sertoli cells |
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NELL1 is an important growth factor for regulation of osteochondral differentiation, by regulating both RUNX2 and SOX9 expression within the calvarium |
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TWIST1 binds directly to SOX9 and inhibits both SOX9-dependent gene activation and SOX9 binding to target gene enhancer DNA in chondrogenic cells |
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MYOCD suppresses SOX9-mediated chondrogenic gene COL2A1 expression |
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ZAK plays an essential role in the onset of chondrogenesis through triggering the induction of SOX6 expression by SOX9 |
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NKX3-2 and SOX9 repress the activity of the PAX3 promoter and NKX3-2 acts as a transcriptional repressor in this process |
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several enhancers contain potential binding sites for SOX9, consistent with its described role as an upstream regulator of ACAN expression |
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TWIST1 bound robustly to the 3'UTR of SOX9, the central initiator of chondrogenesis, suggesting that TWIST1 might directly repress cartilage formation through SOX9 |
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TRPS1 directly represses expression of the hair follicle stem cell regulator SOX9 to control proliferation of the follicle epithelium |
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SOX9 regulates LRP6, TCF4 expression and WNT/CTNNB1 activation in breast cancer |
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both phosphorylation, and to a lesser extent SUMOylation, of SOX9 results in a physical interaction between SNAI2 and SOX9, and SOX9 phosphorylation is necessary to cooperate with SNAI2 to trigger neural crest cell delamination |
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ERG redirects AR to a set of genes including SOX9 that are not normally androgen stimulated, and SOX9 is a critical downstream effector of ERG in TMPRSS2:ERG fusion-positive prostate cancer (PCa) |
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is a transcriptional regulator of IGFBP4 and SOX9-induced activation of IGFBP4 may be one of the mechanisms by which SOX9 suppresses cell proliferation and progression of colon cancer |
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SOX9 does not affect MYOCD expression but significantly reduces the expression of MYOCD/SRF-dependent smooth muscle genes, suggesting that down-regulation of SOX9 is a prerequisite for MYOCD activity |
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NFE2L1 promotes glial fate under direct SOX9 regulatory control |
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chondrocyte maturation driven by SOX9 is antagonized by PAX1 that is downregulated during chondrogenic differentiation |
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SOX8 expression is regulated by SOX9, and both together with SOX5 and SOX6 are required as a SOX quartet for transcription of COL2A1 and a large number of other chondrogenic molecules |
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transcription factors SOX5 and SOX9 caused a significant increase in transactivation of the CATSPER1 promoter in heterologous systems, and both transcription factors interact with the CATSPER1 promoter |
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repression of SOX9 by JAG1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells |
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ZBTB20 regulates the terminal differentiation of hypertrophic chondrocytes by repressing SOX9 |
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SOX9 promotes tumor metastasis and invasion through regulation of S100P expression |
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deacetylation promotes SOX9 nuclear translocation and hence its ability to activate ACAN |
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SOX9 regulation of ETV5 contributes to the control of male fertility |
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DDRGK1 can directly bind to SOX9 to inhibit its ubiquitination and proteasomal degradation |
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GDF6 repressed the melanocyte differentiation gene MITF and the proapoptotic factor SOX9, thereby preventing differentiation, inhibiting cell death, and promoting tumor growth |
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neural retina-specific ALDH1A1 controls dorsal choroidal vascular development via SOX9 expression in retinal pigment epithelial cells |
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MECOM expression correlated with and was directly regulated by SOX9 |