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FLASH GENE

Symbol

CD70

contributors: mct - updated : 18-05-2009

HGNC name	CD70 molecule
HGNC id	11937

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   lower expression in naive B cells from CIVD patients (Groth 2002) tumoral     --over   overexpressed in systemic lupus erythematosus T cells, increasing B cell costimulation and subsequent immunoglobulin overproduction may contribute to drug-induced and idiopathic lupus (Oelke 2004) tumoral     --over   overexpressed in rena cell carcinoma (Diegmann 2006) tumoral     --over   up-regulated more than 1,000 fold in various HTLV1-carrying T cell lines (Baba 2008)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed blood coagulation   blockade of CD70 or ITGAL are promising therapeutic approaches for immune thrombocytopenia cancer hemopathy   potential target for effective antibody therapy against adult T-cell leukemia cancer urinary   potential target antigen for toxin-conjugated therapeutic antibody treatment of renal cell carcinoma

ANIMAL & CELL MODELS