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FLASH GENE

Symbol

CD70

contributors: mct - updated : 18-05-2009

HGNC name	CD70 molecule
HGNC id	11937

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.3      Physical location : 6.585.850 - 6.591.163
Synonym name	tumor necrosis factor (ligand) superfamily, member 7
	Ki-24 antigen
	CD27 ligand on T and some B cells
	cell differentiation antigen CD70
	surface marker for neoplastic cells of Hodgkin lymphoma, identified by monoclonal antibody HNE5
Synonym symbol(s)	CD27LG, CD27L, TNFSF7

DNA

TYPE	functioning gene
STRUCTURE	5.31 kb     3 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 3 - 913 20.9 193 - Bowman (1994)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       highly Nervous brain       lowly Reproductive female system placenta     lowly Respiratory lung       lowly Urinary kidney       highly

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune B cell Lymphoid/Immune T cell

cell lineage
cell lines	various carcinoma cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophilic Hydrophobic
STRUCTURE

motifs/domains	a 20 AA hydrophilic N-terminal domain
	18-amino acid hydrophobic region that presumably functions as a transmembrane anchor
	an extracellular C-terminal domain
	two potential N-linked glycosylation sites

conjugated

GlycoP

mono polymer

homomer , trimer

HOMOLOGY

Homologene

FAMILY

tumor necrosis factor family

CATEGORY

antigen , signaling cytokine

SUBCELLULAR LOCALIZATION	plasma membrane
text	single pass type II membrane protein

basic FUNCTION	acting as a ligand for TNFRSF27/CD27
	inducing proliferation of costimulated T cells, enhancing the generation of cytolytic T cells, and contributing to T cell activation (Goodwin 1993)
	playing a role in regulating B-cell activation, cytotoxic function of natural killer cells and immunoglobulin synthesis
	surface antigen on activated but not on resting, T and B lymphocytes
	is critical for stimulation of an effective cytotoxic T cell response against B cell precursor acute lymphoblastic leukemia (Glouchkova 2009)
	promotes lymphocyte apoptosis through interaction with its receptor and SIVA, contributing to the failure of RCC patients to develop an effective lymphocyte mediated ntitumor response (Diegmann 2006)
	CD70 and ITGAL facilitate the survival of T, B lymphocytes and indirectly enhance the destruction of platelets in immune thrombocytopenia

CELLULAR PROCESS	cell life, proliferation/growth
	cell communication

PHYSIOLOGICAL PROCESS

immunity/defense

text	cell-cell signaling

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

binding to CD27

cell & other

REGULATION

induced by

PGE2, facilitating T-cell/T-cell interaction that warrant long-lasting costimulation (Krause 2009)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   lower expression in naive B cells from CIVD patients (Groth 2002) tumoral     --over   overexpressed in systemic lupus erythematosus T cells, increasing B cell costimulation and subsequent immunoglobulin overproduction may contribute to drug-induced and idiopathic lupus (Oelke 2004) tumoral     --over   overexpressed in rena cell carcinoma (Diegmann 2006) tumoral     --over   up-regulated more than 1,000 fold in various HTLV1-carrying T cell lines (Baba 2008)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed blood coagulation   blockade of CD70 or ITGAL are promising therapeutic approaches for immune thrombocytopenia cancer hemopathy   potential target for effective antibody therapy against adult T-cell leukemia cancer urinary   potential target antigen for toxin-conjugated therapeutic antibody treatment of renal cell carcinoma

ANIMAL & CELL MODELS