protein
| GDF2 and BMP10 are specific ligands for ACVRL1 that potently inhibit microvascular endothelial cell migration and growth |
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ACVRL1/CSNK2B interaction specifically enhanced SMAD1/5/8 phosphorylation |
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high specificity of ACVRL1 for GDF2/BMP10 is determined by a novel orientation of ACVRL1 with respect to GDF2, which leads to a unique set of receptor-ligand interactions |
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type I cell surface receptor for the transforming growth factor-beta (TGFB) family of proteins |
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BMP9 and BMP10 are the physiological, functionally equivalent ligands of ACVRL1 in vascular development |
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BMP10 is the crucial ligand for ACVRL1 in embryonic vascular development, and circulating BMP10 acts through endothelial ACVRL1 to limit endothelial cell number in and thereby stabilize the caliber of nascent arteries |
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GDF2 inhibits lymphatic vessel formation via ACVRL1 during development and cancer progression |
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PPP2R2B protein interacts with the ACVRL1/TGFBR2/ENG complex and recruits PP2A to nitric oxide synthase 3 (NOS3) |
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synergises with NOTCH1 in stalk cells to induce expression of the NOTCH1 targets HEY1 and HEY2 and thereby represses tip cell formation and angiogenic sprouting |