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FLASH GENE

Symbol

PTGFR

contributors: - updated : 14-09-2005

HGNC name	prostaglandin F receptor (FP)
HGNC id	9600

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed FPS - splicing 2565 - 297 heart and placenta, skeletal muscle Vielhauer 71 bp insert producing a frame shift resulting in a truncated receptor lacking transmembrane-7 and the intracellular carboxyl tail FPA - splicing 3466 - 359 - Vielhauer FPB - splicing - - - - Vielhauer

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system prostate       Visual eye anterior segment iris

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective         Epithelial         Muscular smooth       Muscular smouth ciliary

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM)

HOMOLOGY

interspecies

homolog to murine Ptgfr

Homologene

FAMILY

G protein coupled receptor superfamily

CATEGORY

signaling , receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

potent luteolytic agent, may be involved in modulating intraocular pressure and smooth muscle contraction in uterus

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   LOH     in breast cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS