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FLASH GENE
Symbol MUC6 contributors: mct - updated : 07-03-2013
HGNC name mucin 6, oligomeric mucus/gel-forming
HGNC id 7517
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an extended array of simple tandem repeats flanked by cysteine-rich subdomains
  • N terminal WWFD domains
  • C terminal region much shorter, with reduced cysteine residues
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY secretory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • major secreted mucins of the digestive tract, involved in renal morphogenesis processes
  • contribute in mucus formation by forming a tridimensional network via oligomerization domains to protect underlying epithelia against diverse injuries
  • critical protective function in the normal stomach, pancreas and duodenum
  • may inhibit invasion of tumor cells through the basement membrane of the pancreatic duct and slow the development of infiltrating carcinoma
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by NFkappaB and Sp family members
    Tn glycosylation of the MUC6 protein modulates its immunogenicity and promotes the induction of Th17-biased T cell responses
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal neoplasia and in intraepithelial cancer of the pancreas
    tumoral     --other  
    expression pattern of secreted mucins including MUC2 and MUC6 is altered apparently in gastric carcinoma
    tumoral     --over  
    in pancreatic intraductal papillary-mucinous neoplasm
    Susceptibility to H pylori infection
    Variant & Polymorphism other Short MUC6 alleles are associated with H pylori infection
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS