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FLASH GENE

Symbol

MUC6

contributors: mct - updated : 07-03-2013

HGNC name	mucin 6, oligomeric mucus/gel-forming
HGNC id	7517

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005961 33 - 8003 NP_005952 - 2439 - -

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach       specific Homo sapiens Adult Reproductive male system prostate       Respiratory lung

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an extended array of simple tandem repeats flanked by cysteine-rich subdomains
	N terminal WWFD domains
	C terminal region much shorter, with reduced cysteine residues

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

CATEGORY

secretory

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,lumen
	intracellular,cytoplasm,organelle,Golgi

basic FUNCTION	major secreted mucins of the digestive tract, involved in renal morphogenesis processes
	contribute in mucus formation by forming a tridimensional network via oligomerization domains to protect underlying epithelia against diverse injuries
	critical protective function in the normal stomach, pancreas and duodenum
	may inhibit invasion of tumor cells through the basement membrane of the pancreatic duct and slow the development of infiltrating carcinoma

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other	regulated by NFkappaB and Sp family members
	Tn glycosylation of the MUC6 protein modulates its immunogenicity and promotes the induction of Th17-biased T cell responses

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in colorectal neoplasia and in intraepithelial cancer of the pancreas tumoral     --other   expression pattern of secreted mucins including MUC2 and MUC6 is altered apparently in gastric carcinoma tumoral     --over   in pancreatic intraductal papillary-mucinous neoplasm

Susceptibility

to H pylori infection

Variant & Polymorphism other	Short MUC6 alleles are associated with H pylori infection

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS