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FLASH GENE

Symbol

TYRO3

contributors: mct/npt/pgu - updated : 30-01-2010

HGNC name	TYRO3 protein tyrosine kinase
HGNC id	12446

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   significantly elevated in primary melanoma tissue samples and melanoma cell lines and correlates with MITF-M mRNA levels

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer skin   may serve as a target for the development of therapeutic agents for melanoma cancer endocrine thyroid TYRO3/AXL-GAS6 autocrine circuit sustains the malignant features of thyroid cancer cells and targeting the circuit could offer a novel therapeutic approach in this cancer

ANIMAL & CELL MODELS