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FLASH GENE

Symbol

TYRO3

contributors: mct/npt/pgu - updated : 30-01-2010

HGNC name	TYRO3 protein tyrosine kinase
HGNC id	12446

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	15q15.1      Physical location : 41.851.219 - 41.871.534
Synonym name	tyrosine-protein kinase receptor TYRO3 precursor
	tyrosine-protein kinase DTK
	tyrosine-protein kinase RSE
	tyrosine-protein kinase SKY
	tyrosine-protein kinase byk
	Tyro3 protein tyrosine kinase (sea-related receptor
	tyrosine kinase)
Synonym symbol(s)	RSE, SKY, BYK, Brt, Dtk, TIF, FLJ16467
EC.number	2.7.10.1

DNA

TYPE	functioning gene
STRUCTURE	20.29 kb     19 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006293 19 - 3949 NP_006284 96.8 890 - 2005 15964779

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly Reproductive female system ovary     highly   female system uterus cervix   highly Skin/Tegument skin       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two Ig-like domains linked to two fibronectin, type III repeats
	cytoplamic region that contains an intrinsic protein tyrosine kinase domain
	a conserved sequence within the kinase domain and adhesion molecule-like extracellular domains

HOMOLOGY

Homologene

FAMILY	TAM family of receptor tyrosine kinases (RTKs)
	protein kinase superfamily
	Tyr protein kinase family
	AXL/UFO subfamily

CATEGORY

enzyme , protooncogene , receptor membrane G tyrosine

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleolus

basic FUNCTION	involved in the protection of neurons from apoptosis
	involved in the regulation of spermatogenesis
	involved in cell adhesion
	Tyro 3 RTK subfamily plays important roles in regulating hemostasis, megakaryocytopoiesis and platelet function
	Tyro 3 RTK subfamily plays important roles in regulating hemostasis, megakaryocytopoiesis and platelet function

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

receptor tyrosine kinases (RTK), which is composed of three members (TYRO3, AXL and MERTK)

INTERACTION

DNA

RNA

small molecule

protein	receptor for GAS6 and PROS1
	interacting with RANBP9
	upstream regulator of MITF expression (TYRO3 induces MITF-M expression in a SOX10-dependent manner in melanoma cells)
	TULP1 interacts with TYRO3, AXL and MERTK of the TAM receptor tyrosine kinase subfamily, whereas tubby binds only to MERTK

cell & other

REGULATION

activated by

GAS6 and PROS1

Other

regulated by AP-1 in oncogenic activity

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   significantly elevated in primary melanoma tissue samples and melanoma cell lines and correlates with MITF-M mRNA levels

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer skin   may serve as a target for the development of therapeutic agents for melanoma cancer endocrine thyroid TYRO3/AXL-GAS6 autocrine circuit sustains the malignant features of thyroid cancer cells and targeting the circuit could offer a novel therapeutic approach in this cancer

ANIMAL & CELL MODELS