Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

FCGR3B

contributors: mct - updated : 23-12-2015

HGNC name	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
HGNC id	3620

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

FCGR3B

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional         low copy number was associated with glomerulonephritis in the autoimmune disease systemic lupus erythematosus constitutional     --low   may be a common genomic mechanism in the development of SLE, Wegener's granulomatosis and microscopic polyangiitis constitutional   deletion     juxtaposes the 5prime-regulatory sequences of FCGR2C with the coding sequence of FCGR2B, creating a chimeric gene that provides an explanation for SLE risk associated with reduced FCGR3B gene copy number constitutional   deletion     is a risk factor for systemic sclerosis

Susceptibility

to systemic lupus erythematosus (SLE) to systemic lupus erythematosus, primary Sjogren syndrome (pSS), and Wegener granulomatosis (WG) to idiopathic pulmonary fibrosis to non-organ-specific autoimmune diseases

Variant & Polymorphism other	reduced FCGR3B copy number is associated with increased risk of systemic lupus erythematosus (SLE)
	association of FCGR3B copy number with susceptibility to idiopathic pulmonary fibrosis
	role of FCGR3B deletion in the aetiology of non-organ-specific autoimmune diseases, particularly SLE
	low FCGR3B CN increased susceptibility to autoimmune diseases, especially SLE, pSS, and WG

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS