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FLASH GENE

Symbol

FCGR3B

contributors: mct - updated : 23-12-2015

HGNC name	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
HGNC id	3620

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	FCGR3B autoimmune thyroiditis
Location	1q23.3      Physical location : 161.592.989 - 161.601.158
Synonym name	Fc fragment of IgG, low affinity IIIb, receptor for (CD16)
	cell differentiation antigen CD16, 50-65kD, low affinity Fc gamma RIII receptor, glycosyl-phosphatidylinositol (GPI) linked membrane glycoprotein, identified by monoclonal antibodies BW209/2, 3G8, CLB/FcGran, B73.1 (see IGFCR@)
	Fc-gamma RIII-beta
	Fc-gamma receptor IIIb (CD 16)
	low affinity immunoglobulin gamma Fc region receptor III-B
Synonym symbol(s)	CD16, FCG3, FCG3.2, FCR3, CD16b, FCGR3, FcR-10, FcRIII

DNA

TYPE	functioning gene
STRUCTURE	8.77 kb     5 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

motif	repetitive sequence   other
text structure	only FCGR3A, FCGR2C and FCGR3B show CNV

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001244753 5 - 2394 NP_001231682 - 269 - 1997 7662988 NM_000570 6 - 2148 NP_000561 - 233 - 1997 7662988 NM_001271035 5 - 2391 NP_001257964 - 268 - 1997 7662988 NM_001271037 4 - 2002 NP_001257966 - 130 - 1997 7662988 NM_001271036 3 - 2260 NP_001257965 - 216 - 1997 7662988

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     specific Homo sapiens Connective

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic eosinophil Blood/Hematopoietic neutrophil Homo sapiens Adult

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a 16 aa signal peptide
	two Ig-like C2-type (immunoglobulin-like) domains
	a N terminal extracellular domain
	a glycosylphosphatidyl anchor

conjugated

GlycoP , LipoP

mono polymer

monomer

isoforms

Precursor

a 217 aa mature pepetide of 24.6 kda, a soluble form is produced by a proteolytic cleavage

HOMOLOGY

interspecies

ortholog to rattus Fcgr3

Homologene

FAMILY

CATEGORY

receptor

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
text	attached to the membrane by a GPI-anchor
	exists also as a soluble receptor, produced by a proteolytic cleavage

basic FUNCTION	involved in blood transfusion reactions
	immune-mediated neutropenia (NA1, NA2 and SH, with SH variant of NA2)
	acting as a receptor for the Fc region of immunoglobulins gamma
	may serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils
	FCGR3A, FCGR3B are IgG Fc receptors expressed by human natural killer (NK) cells and neutrophils, respectively
	is a GPI-anchored glycoprotein

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

complexed or aggregated IgG and also monomeric IgG

cell & other

REGULATION

inhibited by

glycosylation for the interaction with IgG3

ASSOCIATED DISORDERS

corresponding disease(s)

FCGR3B

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional         low copy number was associated with glomerulonephritis in the autoimmune disease systemic lupus erythematosus constitutional     --low   may be a common genomic mechanism in the development of SLE, Wegener's granulomatosis and microscopic polyangiitis constitutional   deletion     juxtaposes the 5prime-regulatory sequences of FCGR2C with the coding sequence of FCGR2B, creating a chimeric gene that provides an explanation for SLE risk associated with reduced FCGR3B gene copy number constitutional   deletion     is a risk factor for systemic sclerosis

Susceptibility

to systemic lupus erythematosus (SLE) to systemic lupus erythematosus, primary Sjogren syndrome (pSS), and Wegener granulomatosis (WG) to idiopathic pulmonary fibrosis to non-organ-specific autoimmune diseases

Variant & Polymorphism other	reduced FCGR3B copy number is associated with increased risk of systemic lupus erythematosus (SLE)
	association of FCGR3B copy number with susceptibility to idiopathic pulmonary fibrosis
	role of FCGR3B deletion in the aetiology of non-organ-specific autoimmune diseases, particularly SLE
	low FCGR3B CN increased susceptibility to autoimmune diseases, especially SLE, pSS, and WG

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS