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FLASH GENE
Symbol FCGR3B contributors: mct - updated : 23-12-2015
HGNC name Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
HGNC id 3620
Corresponding disease
FCGR3B autoimmune thyroiditis
Location 1q23.3      Physical location : 161.592.989 - 161.601.158
Synonym name
  • Fc fragment of IgG, low affinity IIIb, receptor for (CD16)
  • cell differentiation antigen CD16, 50-65kD, low affinity Fc gamma RIII receptor, glycosyl-phosphatidylinositol (GPI) linked membrane glycoprotein, identified by monoclonal antibodies BW209/2, 3G8, CLB/FcGran, B73.1 (see IGFCR@)
  • Fc-gamma RIII-beta
  • Fc-gamma receptor IIIb (CD 16)
  • low affinity immunoglobulin gamma Fc region receptor III-B
  • Synonym symbol(s) CD16, FCG3, FCG3.2, FCR3, CD16b, FCGR3, FcR-10, FcRIII
    DNA
    TYPE functioning gene
    STRUCTURE 8.77 kb     5 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    motif repetitive sequence   other
    text structure
  • only FCGR3A, FCGR2C and FCGR3B show CNV
  • MAPPING cloned Y linked N status confirmed
    Physical map
    NIT1 1q21-q22 nitrilase 1 DEDD 1q21.3 death effector domain containing HSPC155 1q23.1 hypothetical protein HSPC155 USP21 1q22 ubiquitin specific protease 21 PPOX 1q22 protoporphyrinogen oxidase B4GALT3 1q21-q23 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 ADAMTS4 1q23 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4 NDUFS2 1q23 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) FCER1G 1q23 Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide APOA2 1q21-q23 apolipoprotein A-II FLJ12770 1q23.1 hypothetical protein FLJ12770 NR1I3 1q23.1 nuclear receptor subfamily 1, group I, member 3 MPZ 1q22 myelin protein zero (Charcot-Marie-Tooth neuropathy 1B) SDHC 1q21 succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa LOC257177 1q23.1 similar to hypothetical protein MGC20470 LOC148430 1q23.1 similar to ribosomal protein S2; 40S ribosomal protein S2 LOC388709 1 LOC388709 LOC388710 1 LOC388710 FCGR2A 1q23 Fc fragment of IgG, low affinity IIa, receptor for (CD32) HSPA6 1q heat shock 70kDa protein 6 (HSP70B') FCGR3A 1q23 Fc fragment of IgG, low affinity IIIa, receptor for (CD16) FCGR3B 1q23 Fc fragment of IgG, low affinity IIIb, receptor for (CD16) FCGR2B 1q23 Fc fragment of IgG, low affinity IIb, receptor for (CD32) FREB 1q23.1 Fc fragment of IgG, low affinity IIb, receptor for (CD32) FLJ31052 1q23.1 hypothetical protein FLJ31052 DUSP12 1q22 dual specificity phosphatase 12 ATF6 1q22-q23 activating transcription factor 6
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2394 - 269 - 1997 7662988
    6 - 2148 - 233 - 1997 7662988
    5 - 2391 - 268 - 1997 7662988
    4 - 2002 - 130 - 1997 7662988
    3 - 2260 - 216 - 1997 7662988
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  specific Homo sapiens
    Connective    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticeosinophil
    Blood/Hematopoieticneutrophil Homo sapiensAdult
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 16 aa signal peptide
  • two Ig-like C2-type (immunoglobulin-like) domains
  • a N terminal extracellular domain
  • a glycosylphosphatidyl anchor
  • conjugated GlycoP , LipoP
    mono polymer monomer
    isoforms Precursor a 217 aa mature pepetide of 24.6 kda, a soluble form is produced by a proteolytic cleavage
    HOMOLOGY
    interspecies ortholog to rattus Fcgr3
    Homologene
    FAMILY
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text
  • attached to the membrane by a GPI-anchor
  • exists also as a soluble receptor, produced by a proteolytic cleavage
  • basic FUNCTION
  • involved in blood transfusion reactions
  • immune-mediated neutropenia (NA1, NA2 and SH, with SH variant of NA2)
  • acting as a receptor for the Fc region of immunoglobulins gamma
  • may serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils
  • FCGR3A, FCGR3B are IgG Fc receptors expressed by human natural killer (NK) cells and neutrophils, respectively
  • is a GPI-anchored glycoprotein
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • complexed or aggregated IgG and also monomeric IgG
  • cell & other
    REGULATION
    inhibited by glycosylation for the interaction with IgG3
    ASSOCIATED DISORDERS
    corresponding disease(s) FCGR3B
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    low copy number was associated with glomerulonephritis in the autoimmune disease systemic lupus erythematosus
    constitutional     --low  
    may be a common genomic mechanism in the development of SLE, Wegener's granulomatosis and microscopic polyangiitis
    constitutional   deletion    
    juxtaposes the 5prime-regulatory sequences of FCGR2C with the coding sequence of FCGR2B, creating a chimeric gene that provides an explanation for SLE risk associated with reduced FCGR3B gene copy number
    constitutional   deletion    
    is a risk factor for systemic sclerosis
    Susceptibility
  • to systemic lupus erythematosus (SLE)
  • to systemic lupus erythematosus, primary Sjogren syndrome (pSS), and Wegener granulomatosis (WG)
  • to idiopathic pulmonary fibrosis
  • to non-organ-specific autoimmune diseases
  • Variant & Polymorphism other
  • reduced FCGR3B copy number is associated with increased risk of systemic lupus erythematosus (SLE)
  • association of FCGR3B copy number with susceptibility to idiopathic pulmonary fibrosis
  • role of FCGR3B deletion in the aetiology of non-organ-specific autoimmune diseases, particularly SLE
  • low FCGR3B CN increased susceptibility to autoimmune diseases, especially SLE, pSS, and WG
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS