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FLASH GENE
Symbol RCC1 contributors: mct - updated : 05-02-2011
HGNC name regulator of chromosome condensation 1
HGNC id 1913
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven homologous repeats of 51-68 AAs, which were later shown to adopt a seven-bladed beta-propeller fold
  • beta-propeller domain binds the histone H2A–H2B dimer component of the histone octamer
    • HOMOLOGY
    Homologene
    FAMILY
  • RCC1 superfamily
    • CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    text predominantly located to nucleus in mitotic cells
    basic FUNCTION
  • functioning as a guanine nucleotide exchange factor for the nuclear Ras-like small G protein, RAN/TC4
  • guanine nucleotide exchange factor for the GTPase protein
  • catalyses the formation of RanGTP in the nucleus, whereas hydrolysis of RanGTP is stimulated by RANGAP1 and RANBP1 in the cytoplasm
  • reads the histone code created by caspase-activated Mst1 to initiate apoptosis by reducing the level of RanGTP in the nucleus
  • only known exchange factor for the Ran guanosine triphosphatase and performs essential roles in nuclear transport, spindle organization, and nuclear envelope formation
  • minimal essential function of nucleosomes in nuclear pore complexes (NPCs) formation is to recruit RCC1 and AHCTF1
    • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text
  • nucleoplasmic transport
  • RAN required for chromatin induced mitotic spindle formation
  • nucleus cytoplasmic
  • nuclear envelope assembly
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • histones H2A, H2B docking CHC1 (RCC1) to RAN, enhancer RAN function
  • upregulated C-Myc target gene
  • interacting with METTL11A, predominant alpha-N-methyltransferase for RCC1
  • recruits RAN to nucleosomes and activates RAN nucleotide exchange activity
    • cell & other
  • binding to both DNA and histones, and these effects are tail mediated
  • binding of RCC1 to the nucleosome is central to the formation of this spatial signal within the nucleus
    • REGULATION
    activated by upregulated by cMyc
    Other linked to XPO1 (CRM1) by RANBP3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS