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FLASH GENE

Symbol

RCC1

contributors: mct - updated : 05-02-2011

HGNC name	regulator of chromosome condensation 1
HGNC id	1913

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	33.25 kb     12 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001048194 11 - 2633 NP_001041659 48 452 - 2009 19060893 NM_001048195 11 - 2591 NP_001041660 47 438 - 2009 19060893 NM_001048199 12 - 2715 NP_001041664 45 421 - 2009 19060893 NM_001269 10 - 2540 NP_001260 - 421 - -

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly Reproductive female system uterus cervix   highly Respiratory respiratory tract larynx     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	seven homologous repeats of 51-68 AAs, which were later shown to adopt a seven-bladed beta-propeller fold
	beta-propeller domain binds the histone H2A–H2B dimer component of the histone octamer

HOMOLOGY

Homologene

FAMILY

RCC1 superfamily

CATEGORY

regulatory , DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome
text	predominantly located to nucleus in mitotic cells

basic FUNCTION	functioning as a guanine nucleotide exchange factor for the nuclear Ras-like small G protein, RAN/TC4
	guanine nucleotide exchange factor for the GTPase protein
	catalyses the formation of RanGTP in the nucleus, whereas hydrolysis of RanGTP is stimulated by RANGAP1 and RANBP1 in the cytoplasm
	reads the histone code created by caspase-activated Mst1 to initiate apoptosis by reducing the level of RanGTP in the nucleus
	only known exchange factor for the Ran guanosine triphosphatase and performs essential roles in nuclear transport, spindle organization, and nuclear envelope formation
	minimal essential function of nucleosomes in nuclear pore complexes (NPCs) formation is to recruit RCC1 and AHCTF1

CELLULAR PROCESS	cell cycle, division, mitosis

PHYSIOLOGICAL PROCESS

cellular trafficking transport

text	nucleoplasmic transport
	RAN required for chromatin induced mitotic spindle formation
	nucleus cytoplasmic
	nuclear envelope assembly

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	histones H2A, H2B docking CHC1 (RCC1) to RAN, enhancer RAN function
	upregulated C-Myc target gene
	interacting with METTL11A, predominant alpha-N-methyltransferase for RCC1
	recruits RAN to nucleosomes and activates RAN nucleotide exchange activity

cell & other	binding to both DNA and histones, and these effects are tail mediated
	binding of RCC1 to the nucleosome is central to the formation of this spatial signal within the nucleus

REGULATION

activated by

upregulated by cMyc

Other

linked to XPO1 (CRM1) by RANBP3

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS