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FLASH GENE
Symbol RCC1 contributors: mct - updated : 05-02-2011
HGNC name regulator of chromosome condensation 1
HGNC id 1913
Location 1p35.3      Physical location : 28.832.454 - 28.865.708
Synonym name
  • cell cycle regulatory protein
  • guanine nucleotide-releasing protein
  • chromosome condensation 1
    • Synonym symbol(s) RGLCC, CHC1, HERC2, RCC1-I, SHEP1
    DNA
    TYPE functioning gene
    STRUCTURE 33.25 kb     12 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2633 48 452 - 2009 19060893
    11 - 2591 47 438 - 2009 19060893
    12 - 2715 45 421 - 2009 19060893
    10 - 2540 - 421 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Reproductivefemale systemuteruscervix highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven homologous repeats of 51-68 AAs, which were later shown to adopt a seven-bladed beta-propeller fold
  • beta-propeller domain binds the histone H2A–H2B dimer component of the histone octamer
    • HOMOLOGY
    Homologene
    FAMILY
  • RCC1 superfamily
    • CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    text predominantly located to nucleus in mitotic cells
    basic FUNCTION
  • functioning as a guanine nucleotide exchange factor for the nuclear Ras-like small G protein, RAN/TC4
  • guanine nucleotide exchange factor for the GTPase protein
  • catalyses the formation of RanGTP in the nucleus, whereas hydrolysis of RanGTP is stimulated by RANGAP1 and RANBP1 in the cytoplasm
  • reads the histone code created by caspase-activated Mst1 to initiate apoptosis by reducing the level of RanGTP in the nucleus
  • only known exchange factor for the Ran guanosine triphosphatase and performs essential roles in nuclear transport, spindle organization, and nuclear envelope formation
  • minimal essential function of nucleosomes in nuclear pore complexes (NPCs) formation is to recruit RCC1 and AHCTF1
    • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text
  • nucleoplasmic transport
  • RAN required for chromatin induced mitotic spindle formation
  • nucleus cytoplasmic
  • nuclear envelope assembly
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • histones H2A, H2B docking CHC1 (RCC1) to RAN, enhancer RAN function
  • upregulated C-Myc target gene
  • interacting with METTL11A, predominant alpha-N-methyltransferase for RCC1
  • recruits RAN to nucleosomes and activates RAN nucleotide exchange activity
    • cell & other
  • binding to both DNA and histones, and these effects are tail mediated
  • binding of RCC1 to the nucleosome is central to the formation of this spatial signal within the nucleus
    • REGULATION
    activated by upregulated by cMyc
    Other linked to XPO1 (CRM1) by RANBP3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS