Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | DPYD | contributors: mct - updated : 26-06-2019 |
HGNC name | dihydropyrimidine dehydrogenase |
HGNC id | 3012 |
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Corresponding disease |
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Location | 1p21.3 Physical location : 97.543.301 - 98.386.615 | ||
Synonym name | |||
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Synonym symbol(s) | DPD, DHP, MGC132008, MGC70799, DHPDHase | ||
EC.number | 1.3.1.2 |
DNA |
TYPE | functioning gene |
STRUCTURE | 843.32 kb 23 Exon(s) |
Genomic sequence alignment details |
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10 Kb 5' upstream gene genomic sequence study |
regulatory sequence | Promoter |
cytosine-phosphate-guanine/HTF | |
Binding site transcription factor | |
text structure | |
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MAPPING | cloned | Y | linked | N | status | confirmed |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | ubiquitous |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cells |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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conjugated | FlavoP , PhosphoP |
mono polymer | homomer , dimer |
HOMOLOGY |
interspecies | homolog to C.elegans C25F6-3 |
homolog to rattus Dpyd (89.2pc) | |
homolog to murine Dpyd (89.6pc) |
Homologene |
FAMILY |
CATEGORY | enzyme |
SUBCELLULAR LOCALIZATION | plasma membrane |
intracellular | |
intracellular,cytoplasm,cytosolic |
CELLULAR PROCESS | nucleotide |
PHYSIOLOGICAL PROCESS | circadian |
text | circadian variation of expression |
PATHWAY |
metabolism | aminoacid , purine/pyrimidine |
signaling |
amino acid biosynthesis |
a component |
INTERACTION |
DNA |
RNA |
protein |
cell & other |
REGULATION |
ASSOCIATED DISORDERS |
corresponding disease(s) | DPYD |
Susceptibility |
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Variant & Polymorphism SNP , other | |
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8201;>& | |
8201;C polymorphism may be a predictor of complete remission (CR) for pediatric ALL patients | |
Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |