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FLASH GENE

Symbol

FCGR2B

contributors: mct - updated : 13-02-2015

HGNC name	Fc fragment of IgG, low affinity IIb, receptor for (CD32)
HGNC id	3618

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   translocation     translocation in malignant lymphoma constitutional     --low   in memory B cells from SLE patients, reflecting inadequate inhibitory signaling in SLE memory B cells

Susceptibility

to systemic lupus erythematosus (SLE) to malaria

Variant & Polymorphism SNP	I232T increased in SLE patients (decreasing affinity to lipid rafts and attenuating inhibitory effects on B cell receptor signaling)
	homozygous -343 C/C genotype in the promoter is more frequent in SLE patients
	343G/C promoter polymorphism associated with SLE
	a SNP abrogates receptor function and is strongly associated with susceptibility to SLE, but also associated with substantial protection against severe malaria (Willcocks 2010)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS