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FLASH GENE
Symbol FCGR2B contributors: mct - updated : 13-02-2015
HGNC name Fc fragment of IgG, low affinity IIb, receptor for (CD32)
HGNC id 3618
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • single chain transmembrane (TM) protein containing two Ig extracellular domains
  • a cytoplasmic tail with immunoreceptor tyrosine based inhibitory motifs (ITIM)
    • HOMOLOGY
    interspecies homolog to murine Fcgr2b
    Homologene
    FAMILY
  • immunoglobulin superfamily
    • CATEGORY immunity/defense , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type 1 membrane protein
    basic FUNCTION
  • maintaining gamma immune system homeostasis through negative regulation of immune responses
  • involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells
  • negative regulator of antibody production and inflammatory responses
  • may be having a prominent role in dendritic cell activity in response to interaction with particulate autoantigens (McGaha 2008)
  • contains an ITIM motif and negatively regulates BCR signaling
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CD72 to modify susceptibility to systemic lupus erythematosus
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    translocation in malignant lymphoma
    constitutional     --low  
    in memory B cells from SLE patients, reflecting inadequate inhibitory signaling in SLE memory B cells
    Susceptibility
  • to systemic lupus erythematosus (SLE)
  • to malaria
    • Variant & Polymorphism SNP
  • I232T increased in SLE patients (decreasing affinity to lipid rafts and attenuating inhibitory effects on B cell receptor signaling)
  • homozygous -343 C/C genotype in the promoter is more frequent in SLE patients
  • 343G/C promoter polymorphism associated with SLE
  • a SNP abrogates receptor function and is strongly associated with susceptibility to SLE, but also associated with substantial protection against severe malaria (Willcocks 2010)
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS