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FLASH GENE

Symbol

FCGR2B

contributors: mct - updated : 13-02-2015

HGNC name	Fc fragment of IgG, low affinity IIb, receptor for (CD32)
HGNC id	3618

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	15.01 kb     8 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

regulatory sequence	alternative promoter
	Binding site
text structure	binding sites for ZNF140 and ZNF91 (to repression of FCGR2B transcription)
	interaction of c-Jun with the FCGR2B promoter and c-Jun could act as transcriptional regulator of the FCGR2B promoter activity at this site

MAPPING

cloned

Y

linked

Y

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001002273 7 - 2114 NP_001002273 - 290 - Magnusson (2004) NM_001002274 7 - 2117 NP_001002274 - 291 - Magnusson (2004) NM_001002275 8 - 2171 NP_001002275 - 309 - Magnusson (2004) NM_004001 8 - 2174 NP_003992 - 310 - Magnusson (2004) NM_001190828 - - 2153 NP_001177757 - 303 - -

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       highly Nervous brain diencephalon amygdala     Reproductive female system placenta     highly Respiratory lung         Urinary kidney         Visual eye uvea choroid

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly Epithelial barrier/lining retinal pigment epithelium (RPE)

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune B cell Homo sapiens Adult Lymphoid/Immune lymphocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	single chain transmembrane (TM) protein containing two Ig extracellular domains
	a cytoplasmic tail with immunoreceptor tyrosine based inhibitory motifs (ITIM)

HOMOLOGY

interspecies

homolog to murine Fcgr2b

Homologene

FAMILY

immunoglobulin superfamily

CATEGORY

immunity/defense , receptor

SUBCELLULAR LOCALIZATION	plasma membrane
text	type 1 membrane protein

basic FUNCTION	maintaining gamma immune system homeostasis through negative regulation of immune responses
	involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells
	negative regulator of antibody production and inflammatory responses
	may be having a prominent role in dendritic cell activity in response to interaction with particulate autoantigens (McGaha 2008)
	contains an ITIM motif and negatively regulates BCR signaling

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with CD72 to modify susceptibility to systemic lupus erythematosus

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   translocation     translocation in malignant lymphoma constitutional     --low   in memory B cells from SLE patients, reflecting inadequate inhibitory signaling in SLE memory B cells

Susceptibility

to systemic lupus erythematosus (SLE) to malaria

Variant & Polymorphism SNP	I232T increased in SLE patients (decreasing affinity to lipid rafts and attenuating inhibitory effects on B cell receptor signaling)
	homozygous -343 C/C genotype in the promoter is more frequent in SLE patients
	343G/C promoter polymorphism associated with SLE
	a SNP abrogates receptor function and is strongly associated with susceptibility to SLE, but also associated with substantial protection against severe malaria (Willcocks 2010)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS