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FLASH GENE
Symbol DPAGT1 contributors: mct/npt/pgu - updated : 18-11-2013
HGNC name dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
HGNC id 2995
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Lymphoid/Immunethymus    
Nervousbrain    
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a glycosyl transferase domain
    • HOMOLOGY
    interspecies ortholog to rattus h2afx (90 pc)
    ortholog to murine Dpagt1 (89.95 pc)
    Homologene
    FAMILY
  • glycosyltransferase family 4
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • catalyzing the initial step in the synthesis of dolichol- p-p-oligosaccharides
  • involved in glycosylation of proteins on asparagine amino acids (N-linked) in proteins of eukaryotic cells from dolichol-phosphate and UDP-N-acetylglucosamine
  • playing a fundamental role in the pathway for protein N-glycosylation
  • upstream regulator of E-cadherin N-glycosylation status and adherens junction composition
  • initiates the synthesis of the lipid-linked oligosaccharide precursor for protein N-glycosylation in the endoplasmic reticulum and is a key determinant of the extent of protein N-glycosylation
  • upstream regulator of N-glycosylation status of CDH1 and its diminished expression is required for the formation of mature intercellular adhesion complexes
  • DPAGT1 and GFPT1 are required for protein glycosylation, which in turn is essential for correct protein folding and targeting
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • target of the canonical Wnt/beta-catenin pathway, indicating that Wnt signaling affects protein N-glycosylation
  • JUP interacts with the DPAGT1 promoter through a Wnt-dependent mechanism distinct from that of CTNNB1
  • target of the canonical Wnt signaling pathway (overexpression of DPAGT1 in oral squamous cell carcinoma (OSCC) tumor is linked to aberrant activation of canonical Wnt signaling)
    • cell & other
    REGULATION
    activated by Wnt/beta-catenin pathway that is a direct transcriptional activator of the DPAGT1 gene
    Other its expression was regulated in response to Wnt/beta-catenin signaling through the binding of Tcf/beta-catenin to the TCF/LEF sequence in its promoter
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG1J , CMSTA2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    dysregulation causes disturbances in intercellular adhesion in oral cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS