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FLASH GENE

Symbol

MCL1

contributors: mct/shn - updated : 08-12-2017

HGNC name	myeloid cell leukemia sequence 1 (BCL2-related)
HGNC id	6943

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	Deletion of Mcl-1 resulted in peri-implantation embryonic lethality in mouse (
	mice conditional for Mcl-1 display a profound reduction in B and T lymphocytes when MCL-1 is removed, deletion of Mcl-1 during early lymphocyte differentiation increased apoptosis and arrested the development at pro-B-cell and double-negative T-cell stages (
	deletion of Mcl-1 in cortical neurons of transgenic mice activates a robust autophagic response