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FLASH GENE
Symbol ARHGDIB contributors: mct/npt - updated : 19-10-2009
HGNC name Rho GDP dissociation inhibitor (GDI) beta
HGNC id 679
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to Aplysia
Homologene
FAMILY
  • RHO GDI family
    • CATEGORY immunity/defense , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text membrane-bound vesicles
    basic FUNCTION
  • regulating the GDP/GTP exchange reaction of the RHO proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them
  • metastasis suppressor gene and its targets, endothelin-1 and Neuromedin U are excellent potential targets for therapeutic intervention in the metastatic cascade (Harding 2007)
  • abundantly expressed in haematopoetic cells and possibly plays a role in the onset of apoptosis (Ma 2007)
  • suppressor of metastasis in human bladder cancer (Wu 2009)
  • inhibit the activation of small GTPases of the Rho family by sequestering the GTPases in the cytosol and blocking activation by guanine nucleotide exchange factors (GEFs) (Wu 2009)
  • regulator of Rho family GTPase (Cho 2009)
  • involved in gastric tumor growth and metastasis (Cho 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • endothelin-1 and Neuromedin U are two molecular effectors of ARHGGDIB signaling (Harding 2007)
    • cell & other
    REGULATION
    Other phosphorylation by SRC enhances ARHGDIB metastasis suppression and that loss of SRC relieves metastasis suppression in tumor cells that maintain ARHGDIB expression (Wu 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in many metastatic bladder cancers (Wu 2009)
    tumoral     --low  
    is associated with decreased survival for patients with bladder cancer (Theodorescu 2004)
    tumoral     --low  
    lack of expression is a frequent feature of Hodgkin lymphoma but that it is not of vital importance for the growth and survival of these cells (Ma 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene useful marker for tumor progression of human gastric cancer (Cho 2009)
    Marker
    Therapy target
    ANIMAL & CELL MODELS