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FLASH GENE
Symbol SERPINA4 contributors: - updated : 30-12-2005
HGNC name serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
HGNC id 8948
Location 14q32.1      Physical location : 95.027.782 - 95.036.241
Synonym name
  • kallistatin (kallikrein binding protein)
  • protease inhibitor 4 (kallistatin)
    • Synonym symbol(s) KAL, KST, PI4, KLST, KAL
    EC.number 3.4.21.35
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 8.00 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmoothvessel  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    cell lineage
    cell lines
    fluid/secretion plasma
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    mono polymer homomer , monomer
    HOMOLOGY
    Homologene
    FAMILY serpin family
    CATEGORY enzyme , regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • playing a role in the inhibition of angiogenesis and of tumor growth
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cardiovascular
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • kallikrein binding
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS