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FLASH GENE
Symbol ROM1 contributors: npt/ - updated : 29-12-2006
HGNC name retinal outer segment membrane protein 1
HGNC id 10254
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
Homologene
FAMILY
  • RDS (peripherin)/ROM1 family
  • PRPH2/ROM1 family
    • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • regulation of disk morphogenesis and viability of rod phosphoreceptors
  • may function as an adhesion molecule involved in stabilization and compaction of outer segment disks
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • probably forms a complex with a RDS homodimer
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource Retinal Information Network
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    double heterozygotes mutation in RDS and ROM1 develop retinitis pigmentosa (Kajiwara 1994)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS