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FLASH GENE

Symbol

MAP1A

contributors: shn/npt - updated : 15-11-2009

HGNC name	microtubule-associated protein 1A
HGNC id	6835

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	heavy chain and light chain LC2
	caldesmon domain

HOMOLOGY

interspecies	ortholog to Map1a, Rattus norvegicus
	ortholog to MAP1A, Pan troglodytes
	ortholog to Mtap1a, Mus musculus

Homologene

FAMILY

microtubule associated protein family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule

basic FUNCTION	involved in microtubule assembly
	involved in the filamentous cross-bridging between microtubules and other skeletal elements
	implicated in dendritic differentiation and maintenance
	important for dendritic growth and activity-driven dendritic remodelling (Szebenyi 2005)
	a role in early events of spinal cord development
	mediates interactions between microtubules and actin, and also binds components of the postsynaptic density (Conde 2009)

CELLULAR PROCESS

cell organization/biogenesis

PHYSIOLOGICAL PROCESS

text	cell shape and cell size control

PATHWAY

metabolism

signaling

a component

3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins

INTERACTION

DNA

RNA

small molecule

protein	cyclic AMP (cAMP)-binding domain of exchange protein directly activated by cyclic AMP 1 RAPGEF3, to enhance Rap1 GTPase activity and cell adhesion
	disrupted-In-Schizophrenia 1 (DISC1)
	adaptor protein 1 (AP-1)
	postsynaptic density-93 (PSD-93)
	tubulin
	G-actin and F-actin
	MAP1A and MAP1B interact with SNTA1 in the central and peripheral nervous system

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to hearing loss

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS