basic FUNCTION
| transduction adaptor protein SHC |
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signaling adapter that couples activated growth factor receptors to signaling pathway |
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plays a crucial role in linking stimulated receptors to mitogen-activated protein kinase activation through the formation of dynamic signalling complexes |
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play a non-redundant role in cytoskeletal reorganization-induced Erk activation by cytochalasin D |
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role of SHC1 in the assembly and/or maintenance of the subventricular zone (SVZ) neural stem cells (NSCs) niche in the adult brain |
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SHC1 might play a pivotal role in mediating immunogenic and tolerogenic properties of Dendritic cells |
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is required for integrin-mediated spreading and migration specifically on fibronectin, as well as endothelial cell survival in response to VEGFA |
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is the key effector driving vascular hyperglycemic memory in diabetes |
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SHC1 scaffold therefore directs the temporal flow of signalling information after EGF stimulation |
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is a critical regulator of actin dynamics in mast cells, providing a basis for understanding the molecular mechanisms involved in vesicle-mediated secretion in these cells |
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negative regulator of B-cell chemotaxis, suggesting a role for this adaptor in the control of B-cell homing (pMID: 24556683) |
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has a pro-oxidant and pro-apoptotic activity and is implicated in the aging process |
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hypercholesterolemia stimulates p66Shc expression in platelets, promoting platelet oxidative stress, hyperreactivity and hyperaggregation via p66Shc |
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important role for the adapter protein SHC1 in later stages of thymic T cell development and in peripheral T cell-dependent events |
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is a determinant of the epithelial phenotype by repressing TGFB1-induced SMAD activation through differential partitioning of receptor complexes at the cell surface |
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involved in in regulating renal vascular tone and the development of renal vascular dysfunction associated with hypertension-induced nephropathy |
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is a regulator of renal vascular tone and a driver of impaired renal vascular function in hypertension-induced nephropathy |
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SHC1 scaffold, a central regulator of tyrosine kinase signalling, is essential for promoting breast cancer immune suppression |
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is a cytoplasmic signaling protein that supports signal transduction by receptor protein-tyrosine kinases by providing auxiliary tyrosine phosphorylation sites that engage additional signaling proteins |
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SHC1 is a key validated downstream effector of DDR2 signalling and is essential for multiple biological functions such as axon regeneration |
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SHC1 is dispensable for the regulation of DDR2 receptor localisation and phosphorylation dynamics |
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plays a role in insulin signaling, stress resistance and energy metabolism |