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FLASH GENE
Symbol RAB5C contributors: mct - updated : 20-05-2016
HGNC name RAB5C, member RAS oncogene family
HGNC id 9785
Location 17q21.2      Physical location : 40.276.997 - 40.307.022
Synonym name RAB, member of RAS oncogene family-like
Synonym symbol(s) RABL, RAB5CL, L1880, RAB5L
DNA
TYPE functioning gene
STRUCTURE 30.07 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1918 - 249 - 2012 22734003
7 - 1819 - 216 - 2012 22734003
6 - 1702 - 216 - 2012 22734003
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   highly
Reproductivefemale systemplacenta  highly
Respiratorylung    
 respiratory tractlarynx  highly
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated LipoP
HOMOLOGY
Homologene
FAMILY
  • small gtpase superfamily
  • rab family
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • GTPasel, involved in endocytosis
  • protein transport, probably involved in vesicular traffic
  • regulatory role for RAB5A, RAB5B, RAB5C in not only the early endocytic pathway, but also the late endocytic pathway, of membrane trafficking in coordination with PI(3)K activity
  • selective association of RAB5A and RIN1 contributes to the dominance of RAB5A in EGFR trafficking, whereas RAB5B, RAB5C may have major functions unrelated to the EGFR degradation pathway
  • role of RAB5A, RAB5B, RAB5C as endosome organizer revealing the resilience mechanisms of the endocytic system
  • RAB5A, RAB5B, RAB5C are principal components of early endosome biogenesis
  • RAB5A, RAB5B, RAB5C selectively oversee the multiple signaling and trafficking events associated with the endocytic network
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding EEA1
  • GTP-RAB5C bound to ASAP1, and activation of RAB5C by EGFR signaling was necessary to promote the intracellular association of ASAP1 and PRKD2
  • is selectively associated with the growth factor-activation of RAC1 and with enhanced cell motility
  • PLP2 and RAB5C are novel TPD52 binding partners
  • RAB5C is a new TBC1D16 target and it regulates EGFR in melanoma cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS