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FLASH GENE
Symbol MEOX1 contributors: mct/npt/pgu - updated : 15-02-2013
HGNC name mesenchyme homeobox 1
HGNC id 7013
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helix-turn-helix, homeobox DNA binding domain
    • HOMOLOGY
    interspecies ortholog to murine Meox1
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation
  • activating NKX3-2 (activates the NKX3-2 promoter in a dose-dependent manner and this activity is enhanced in the presence of PAX11 and/or PAX9)
  • required for NKX3-2 expression in the sclerotome
  • play role with GLI2 in the commitment of cells to the skeletal muscle lineage
  • part of a regulatory circuit that serves an essential, non-redundant function in the maintenance of rostro-caudal sclerotome polarity and axial skeleton formation
  • MEOX1 can specifically bind the DNA sequences recognized by HOXA2 on its functional target genes
  • MEOX1 and MEOX2 have been shown to be partially functionally redundant during development, suggesting that they regulate similar target genes
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • regulates the MEOX2 target genes CDKN1A and CDKN2A
    • cell & other
    REGULATION
    Other regulated by a regulatory loop between GLI2, MEOX1, and PAX3 that is essential for specification of mesodermal cells into the muscle lineage
    ASSOCIATED DISORDERS
    corresponding disease(s) KFS2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS