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FLASH GENE

Symbol

OTX2

contributors: mct/npt/pgu/shn - updated : 04-04-2018

HGNC name	orthodenticle homeobox 2
HGNC id	8522

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	by ectopical expression of Otx2 in the presumptive anterior hindbrain using a knock-in mousestrategy into the En1 locus in, animals display a cerebellar ataxia, brains reveal that most of the anterior cerebellar vermis is missing, whereas the inferior colliculus is complementarily enlarged (
	mice homozygous for Otx2 deficiency in early head development and pituitary oral ectoderm exhibit craniofacial defects and pituitary gland dysmorphology, but normal pituitary cell specification