| basic FUNCTION
| playing a major role in gastrulation |
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essential for the early specification of neuroectoderm destined to become fore midbrain |
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involved in the formation of optic vesicle and retinogenesis |
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development of anterior neural plate specification and organization of the primitive streak |
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required for anterior brain, eye, and antenna formation and for regulating the development of photoreceptors and the expression of rhodopsin |
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transcription factor with an essential role in the development of the cerebellum |
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plays essential roles in the formation and patterning of the rostral brain |
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an essential regulator of the identity, extent and fate of neuronal progenitor domains in the ventral midbrain  |
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may be a medulloblastoma oncogene |
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required for anterior neural plate induction, the region fated to become the anterior pituitary gland |
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involved in the pituitary function |
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may play a role in development of the retinal pigment epithelium and photoreceptor differentiation |
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required for regionalization and patterning of the developing brain and plays an important role in establishing the identity and fate of progenitor neurons |
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required for the formation of all forebrain- and midbrain-derived structures |
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OTX1 and OTX2 are important in neuronal cell development and differentiation: OTX1 primarily in the neocortex, and OTX2 in the archicortex, diencephalon, rostral brain stem, and cerebellum |
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controls neuron subtype identity by antagonizing molecular and functional features of dorsal-lateral ventral tegmental area and may antagonize vulnerability to the Parkinsonian toxin methyl-4-phenyl-1,2,3,6-tetrahydropyridine-HCl ( |
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critical regulator of vertebrate photoreceptor genesis |
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regulates retinal photoreceptor cell fate determination |
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is required to maintain the embryonic stem cells (ESCs) metastable state by antagonizing ground state pluripotency and promoting commitment to differentiation |
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is a novel intrinsic determinant controlling the functional integrity of ESCs and epiblast stem cells (EpiSCs) |
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OTX2 is a molecular correlate of different pluripotent cell types |
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as in the embryo, OTX2 is crucially required to confer anterior character to ESC-derived neuroectoderm progenitors |
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acts as a master regulator of choroid plexuses (ChPs) development, thereby influencing one of the principal sources of signaling in the developing brain, the cerebrospinal fluid (CSF) |
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plays essential roles in each site at each step of head development |
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SOX6 and OTX2 control the specification of substantia nigra and ventral tegmental area dopamine neurons |
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is a homeodomain transcription factor that is necessary for normal head development |
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acts downstream of MYCN and is essential for patterning and spatial restriction of the sensory domain of the mammalian cochlea |
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plays a critical role in very early neurogenesis, but can become oncogenic when aberrantly expressed later in life |
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upon the induction of ESC differentiation, OTX2 alone or in combination with POU5F1 engages new enhancers, which are silent in undifferentiated ESCs |
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OTX2, ONECUT1 and possibly other Onecut proteins have likely a broad role in coordinating cone development and function |
