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FLASH GENE
Symbol EMX2 contributors: mct - updated : 21-05-2013
HGNC name empty spiracles homeobox 2
HGNC id 3341
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helix-turn-helix DNA binding domain, 61 amino-acid homeobox
    • HOMOLOGY
    interspecies homolog to Drosophila empty spiracles (ems) 2
    homolog to murine Emx2
    homolog to C.elegans Wo2b8.1
    intraspecies homolog to EMX1
    homolog to VAX1
    Homologene
    FAMILY EMX family of homeobox protein
    CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in brain development, normal growth and maturation of hippocampus
  • functioning in combinations with OTX1/2 to specify cell fates in the developing central nervous system
  • suppress choroid plexus development and promote neuroepithelial cell fate
  • FGF8, FGF17 and EMX2 play distinct roles in the molecular regionalization of frontal cortex subdivisions (
  • with FOXG1, inhibit gliogenesis and promote neuronogenesis
  • may have important roles as a novel suppressor in human lung cancer
  • HOXA10 and EMX2 are two transcription factors necessary for female Müllerian duct differentiation and development
    • CELLULAR PROCESS nucleotide, transcription
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PAX6
  • ODZ1 is the first EMX2 target gene
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EMX2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in endometrial cancer (see TSG10B)
    tumoral     --low  
    in lung cancer and this downregulation was associated with methylation of the EMX2 promoter
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS