basic FUNCTION
| involved in intracellular signal transduction in response to PDGF, EGF, insulin |
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inhibiting interleukin 6 signal transduction |
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catalytic activity required for FGF2-induced Ca2+ mobilization |
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plays an essential role in IL3 signal transduction in both catalytic-dependent and -independent manners |
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plays diverse roles in signal transduction including signaling via the RAS-mitogen activated protein kinase (MAPK) pathway |
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tyrosine phosphatase which functions as a positive regulator downstream of RTKs, activating growth-stimulatory signalling pathways |
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playing an essential role in normal hematopoiesis and inducing aberrant hyperactivation of the Ras-Erk pathway |
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modulates and regulates signaling through numerous pathways, many of which are active in the developing endocardial cushions and implicated the ERK pathway as a central mechanism  |
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mediates dephosphorylation of ROCK2 and, therefore, regulates RhoA-induced cell rounding, indicating that it couples with RhoA signaling to control ROCK2 activation during deadhesion  |
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having a role in adhesion-dependent activation of the RhoA family small GTPases  |
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promotes HER2-induced signaling and transformation at least in part by dephosphorylating a negative regulatory autophosphorylation site  |
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regulates tyrosine phosphorylation of NEDD9, hence opposing the effect of kinases, and is a negative regulator of cell migration mediated by NEDD9 ( |
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involved in the SEMA4D-signaling in the developing nervous system  |
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regulating myogenesis by coupling to PTK2 signaling pathway  |
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PTPN11-mediated Ras-mitogen-activated protein kinase (Ras-MAPK) signaling plays a critical role in Müller cell maturation and function, which is necessary for the survival of retinal neurons  |
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role in controlling Ras signaling, and retinal degeneration caused by aberrant receptor tyrosine kinase (RTK)-Shp2 signaling may be prevented by direct intervention in the Ras-MAPK pathway  |
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its signaling may play equally important roles in retinal survival in both physiological and pathological conditions  |
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governs the opposing functions of parafibromin, deregulation of which may cause the development of tumors or developmental malformations)  |
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important role in STAT5 activation and growth factor -mediated proliferation, survival, and differentiation of human progenitor cells  |
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required for induction of CEBPA expression and granulopoiesis in response to CSF3 or other cytokines independent of PTPN11-mediated ERK activation  |
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positive role in the activation of the RAS/MAPK ERK1/2 pathway  |
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positively regulates GH-evoked ERK activation, possibly through its catalytic activity  |
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is required for efficient recovery of cell–cell junctions and for restoration of the endothelial barrier function  |
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SHP2 also promotes the mobility of CDH5 in the plasma membrane, stimulating the reassembly of adherens junctions, the closure of intercellular gaps, and restoration of endothelial integrity  |
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role for PTPN11 as a nutrient-sensing regulator in skeletal myoblasts that is required for the activation of RPS6KB1  |
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involvement in regulating the focal adhesions (FAs) and the cytoskeleton for force maintenance and organization  |
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playing an important role in determining the mechanical polarity in cellular response to matrix rigidity  |
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regulates focal adhesion kinase to promote EGF-induced lamellipodia persistence and cell migration  |
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widely expressed protein tyrosine phosphatase required for signal transduction from multiple cell surface receptors  |
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is essential for spermatogonial stem cells (SSCs) to maintain fertility and the pathogenesis of infertility in humans with PTPN11 mutations is due to compromised SSC functions that block spermatogenesis  |
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FRS2-PTPN11 complex is the key mediator of FGF signaling in lens development  |
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promotes the invasion and metastasis of oral cancer cells  |
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involved in the process of EMT and HOOK1 repressed EMT by regulating the activation of PTPN11  |
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promotes activation of RAS-Erk and PI3K-AKT1 and is crucial for hematopoietic cell function  |
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its phosphatase function positively regulates CLEC7A- and TDGF1P3-stimulated ROS production in macrophages by dephosphorylating and thus mitigating the inhibitory function of SIRPA and by promoting Erk activation  |