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FLASH GENE
Symbol GSC contributors: mct - updated : 22-08-2011
HGNC name goosecoid
HGNC id 4612
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
helix-turn-helix, DNA binding domain
HOMOLOGY
interspecies homolog to Xenopus goosecoid
Homologene
FAMILY paired homeobox family, bicoid subfamily
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
text
  • localized specifically to nuclei 5)
    • basic FUNCTION
  • involved in gastrulation process
  • may play a role in spatial programing within discrete embryonic fields or lineage compartements during organogenesis
  • promoting tumor cell malignancy
  • functions as a transcriptional repressor either by direct DNA binding to paired TAAT homeodomain sites or through recruitment by the forkhead/winged helix transcription factor FOXH1
  • having an essential role in craniofacial and joint development, suggesting that GSC is an essential regulator of mesodermal patterning in mammals and that it has specific functions in neural crest cell derivatives
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • WWP2 influences craniofacial patterning through its interactions with Goosecoid (GSC), a paired-like homeobox transcription factor that has an important role in craniofacial development
  • interacts exclusively with SMAD2, SMAD3 and S
    • cell & other
    REGULATION
    Other post-translationally modified by small ubiquitin-like modifier proteins (SUMO)
    ASSOCIATED DISORDERS
    corresponding disease(s) SAMS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer, with metastasis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS