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FLASH GENE
Symbol KCNA6 contributors: - updated : 29-12-2005
HGNC name potassium voltage-gated channel, shaker-related subfamily, member 6
HGNC id 6225
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrain    
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six putative membrane-spanning domains (6TM)
  • an hydrophobic pore including the P domain with the K+ channel signature,
  • flanked by TM domains 5 and 6, sensitive to changes in membrane potential
    • mono polymer tetramer , complex
    HOMOLOGY
    interspecies homolog to murine Kv1.6
    Homologene
    FAMILY Drosophila shaker-related subfamily member 6
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    basic FUNCTION
  • mediating the voltage-dependent potassium ion permeability of excitable membranes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing through its cytoplasmic segment T1 facing the membrane pore with four beta subunits forming the associated cytoplasmic auxiliary subunits
    • INTERACTION
    DNA
    RNA
    small molecule
    protein associating with the N terminus region of alpha subunit
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS