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FLASH GENE

Symbol

KCNA6

contributors: - updated : 29-12-2005

HGNC name	potassium voltage-gated channel, shaker-related subfamily, member 6
HGNC id	6225

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Nervous brain         Respiratory lung

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	six putative membrane-spanning domains (6TM)
	an hydrophobic pore including the P domain with the K+ channel signature,
	flanked by TM domains 5 and 6, sensitive to changes in membrane potential

mono polymer

tetramer , complex

HOMOLOGY

interspecies

homolog to murine Kv1.6

Homologene

FAMILY

Drosophila shaker-related subfamily member 6

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
	intracellular,nucleus

basic FUNCTION

mediating the voltage-dependent potassium ion permeability of excitable membranes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

complexing through its cytoplasmic segment T1 facing the membrane pore with four beta subunits forming the associated cytoplasmic auxiliary subunits

INTERACTION

DNA

RNA

small molecule

protein

associating with the N terminus region of alpha subunit

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS