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FLASH GENE
Symbol CCL7 contributors: - updated : 29-12-2005
HGNC name chemokine (C-C motif) ligand 7
HGNC id 10634
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a signal peptide sequence
secondary structure a three-stranded antiparallel beta sheet covered on one face by an alpha helix
conjugated GlycoP
mono polymer homomer , monomer , dimer
HOMOLOGY
interspecies homolog to murine Ccl7
homolog to Drosophila eg:bacr25b3.3
homolog to C.elegans K04c2.5
intraspecies homolog to CCL2
homolog to CCL8
Homologene
FAMILY
  • C-C subfamily of chemokines
  • intecrine beta family
    • CATEGORY immunity/defense , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION
  • attracting monocytes and eosinophils, basophil, activated T cell and dendritic cell but not neutrophils
  • attracting macrophages furing inflammation and metastasis
  • augmenting monocyte anti-tumor activity
  • inducing the release of gelatinase B
    • CELLULAR PROCESS cell communication
    cell migration & motility
    PHYSIOLOGICAL PROCESS homeostasis , immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling signal transduction
  • cell-cell signaling
  • calcium Ca2+ homeostasis
    • a component dimer with the so-called alpha beta sandwich structural motif
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to heparin, CCR1, CCR2 and CCR3
  • being an substate of matrix metaloproteinase 2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to multiple sclerosis
    Variant & Polymorphism CA/GA microsatellite polymorphism in the promoter-enhancer region
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS