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FLASH GENE
Symbol CCL7 contributors: - updated : 29-12-2005
HGNC name chemokine (C-C motif) ligand 7
HGNC id 10634
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text clustered in IMC1@
STRUCTURE 2.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map see CCL3L1
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemuterus   
 female systemplacenta   
Skin/Tegumentskin    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a signal peptide sequence
secondary structure a three-stranded antiparallel beta sheet covered on one face by an alpha helix
conjugated GlycoP
mono polymer homomer , monomer , dimer
HOMOLOGY
interspecies homolog to murine Ccl7
homolog to Drosophila eg:bacr25b3.3
homolog to C.elegans K04c2.5
intraspecies homolog to CCL2
homolog to CCL8
Homologene
FAMILY
  • C-C subfamily of chemokines
  • intecrine beta family
    • CATEGORY immunity/defense , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION
  • attracting monocytes and eosinophils, basophil, activated T cell and dendritic cell but not neutrophils
  • attracting macrophages furing inflammation and metastasis
  • augmenting monocyte anti-tumor activity
  • inducing the release of gelatinase B
    • CELLULAR PROCESS cell communication
    cell migration & motility
    PHYSIOLOGICAL PROCESS homeostasis , immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling signal transduction
  • cell-cell signaling
  • calcium Ca2+ homeostasis
    • a component dimer with the so-called alpha beta sandwich structural motif
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to heparin, CCR1, CCR2 and CCR3
  • being an substate of matrix metaloproteinase 2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to multiple sclerosis
    Variant & Polymorphism CA/GA microsatellite polymorphism in the promoter-enhancer region
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS