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FLASH GENE
Symbol DCT contributors: mct - updated : 12-07-2023
HGNC name dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)
HGNC id 2709
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • signal peptide
  • 15 cysteine residues
  • two copper-binding domains
  • a C terminal spanning region
    • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • tyrosinase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic,granule
    text type I membrane protein
    basic FUNCTION
  • DOPAchrome tautomerase involved in melanin pigment biogenesis
  • regulating eumelanin and pheomelanin levels, its enzymatic activity may play a role in determining whether the eumelanin or pheomelanin pathway is preferred for pigment biosynthesis
  • important regulatory enzyme that plays a pivotal role in the biosynthesis of melanin and in the rapid metabolism of its toxic intermediates
  • TYRP1 and DCT, exhibit specific expression in melanocytes, while also contributing to melanin synthesis within melanosomes
  • is involved in the melanogenesis pathway, catalyzing the tautomerization of dopachrome to 5,6-dihydroxyindole-2-carboxylic acid (DHICA)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    a component
  • forming a complex with TYR and TRP1
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • copper Cu2+
    • protein
  • TYRP1 and DCT, modulate TYR activity and stabilize the TYR protein
    • cell & other
    REGULATION
    Other regulated by neurofibromin
    ASSOCIATED DISORDERS
    corresponding disease(s) OCA8
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS