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FLASH GENE

Symbol

DCT

contributors: mct - updated : 12-07-2023

HGNC name	dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)
HGNC id	2709

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	OCA8 oculocutaneous albinism, type VIII
Location	13q32.1      Physical location : 95.091.842 - 95.131.936
Synonym name	dopachrome tautomerase
	L-dopachrome Delta-isomerase
Synonym symbol(s)	TRP-2, TYRP2
EC.number	5.3.3.12

DNA

TYPE	functioning gene
STRUCTURE	112.60 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001922 8 - 5074 NP_001913 59.1 519 - 1998 9480844 NM_001129889 10 - 5173 NP_001123361 - 552 - 1998 9480844 NM_001322182 7 - 4289 NP_001309111 - 208 - 1998 9480844 NM_001322185 8 - 4589 NP_001309114 - 208 - 1998 9480844 NM_001322183 8 - 4343 NP_001309112 - 208 - 1998 9480844 NM_001322184 9 - 4643 NP_001309113 - 208 - 1998 9480844 NM_001322186 10 - 4858 NM_001322186 - 456 - 1998 9480844

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system breast mammary gland     Skin/Tegument skin         Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Epithelial barrier/lining

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument melanocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	signal peptide
	15 cysteine residues
	two copper-binding domains
	a C terminal spanning region

conjugated

MetalloP

HOMOLOGY

Homologene

FAMILY

tyrosinase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,cytosolic,granule
text	type I membrane protein

basic FUNCTION	DOPAchrome tautomerase involved in melanin pigment biogenesis
	regulating eumelanin and pheomelanin levels, its enzymatic activity may play a role in determining whether the eumelanin or pheomelanin pathway is preferred for pigment biosynthesis
	important regulatory enzyme that plays a pivotal role in the biosynthesis of melanin and in the rapid metabolism of its toxic intermediates
	TYRP1 and DCT, exhibit specific expression in melanocytes, while also contributing to melanin synthesis within melanosomes
	is involved in the melanogenesis pathway, catalyzing the tautomerization of dopachrome to 5,6-dihydroxyindole-2-carboxylic acid (DHICA)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

aminoacid

signaling

a component

forming a complex with TYR and TRP1

INTERACTION

DNA

RNA

small molecule	metal binding,
	copper Cu2+

protein

TYRP1 and DCT, modulate TYR activity and stabilize the TYR protein

cell & other

REGULATION

Other

regulated by neurofibromin

ASSOCIATED DISORDERS

corresponding disease(s)

OCA8

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS