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FLASH GENE

Symbol

ZNF146

contributors: mct - updated : 21-03-2009

HGNC name	zinc finger protein 146
HGNC id	12931

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	ten Krüppel-like zinc finger motifs
	three zinc fingers at the C-terminus interact with a region of TERF2IP located downstream of the coil domain

conjugated

MetalloP

HOMOLOGY

Homologene

FAMILY

krueppel C2H2-type zinc-finger protein family

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	transcription factor regulator
	having a function that may be linked to telomere regulation

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   amplification     or overexpressed in pancreatic carcinoma and contributing to the progression of tumor tumoral     --over   in the majority of pancreatic cancers and in more than 80 p100 of colorectal cancers

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive colon potential therapeutic target in colorectal cancer

ANIMAL & CELL MODELS