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FLASH GENE

Symbol

ZNF146

contributors: mct - updated : 21-03-2009

HGNC name	zinc finger protein 146
HGNC id	12931

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	24.17 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	cytosine-phosphate-guanine/HTF
	Binding site
text structure	one CpG island, several regulatory elements

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

text	Variants 1, 2, and 3 encode the same protein

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001099638 3 - 3806 NP_001093108 33.2 292 - 2005 15881673 NM_001099639 3 - 3765 NP_001093109 33.2 292 - 2005 15881673 NM_007145 4 - 3880 NP_009076 33.2 292 - 2005 15881673

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver         Nervous brain       lowly Reproductive female system breast       Respiratory lung       lowly Urinary kidney       lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular     Muscular striatum cardiac     Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol reproductive mammary gland

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	ten Krüppel-like zinc finger motifs
	three zinc fingers at the C-terminus interact with a region of TERF2IP located downstream of the coil domain

conjugated

MetalloP

HOMOLOGY

Homologene

FAMILY

krueppel C2H2-type zinc-finger protein family

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	transcription factor regulator
	having a function that may be linked to telomere regulation

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   amplification     or overexpressed in pancreatic carcinoma and contributing to the progression of tumor tumoral     --over   in the majority of pancreatic cancers and in more than 80 p100 of colorectal cancers

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive colon potential therapeutic target in colorectal cancer

ANIMAL & CELL MODELS