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FLASH GENE
Symbol DGKA contributors: mct/npt - updated : 30-01-2009
HGNC name diacylglycerol kinase, alpha 80kDa
HGNC id 2849
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Lymphoid/Immunespleen   highly
 thymus   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
Nervousglia
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two N terminal EF hand calcium-binding domains
  • two phorbol esters/diacylglycerol binding domain (C1 domain)
  • a DAG catalytic domain
  • a DAG accessory domain
  • existence of additional domains that confer specific plasma membrane localization (Merino 2007)
  • at least two cysteine-rich motifs of unknown function
  • a conserved C-terminal domain, essential for membrane binding in a phosphatidic acid-dependent manner (Merino 2007)
    • mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • eukaryotic diacetylglycerol kinase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • converting diacylglycerol to phosphatidic acid
  • protein kinase C activator
  • regulates the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes (Alonso 2005)
  • phosphorylates diacylglycerol to phosphatidic acid, modifying the cellular levels of these two lipid mediators (Merino 2007)
  • acting as a negative modulator of diacylglycerol-based signals during T cell activation (Merino 2007)
  • playing a role on the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes (Alonso 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
    cell & other
    REGULATION
    Other modulating (phosphorylated) protein kinase C
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS