| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
| fusion
| translocation
|
| protein chimeric
|
|
chronic myelomonocytic leukemia (CMML) and malignant eosinophil proliferation with translocations t(5;12)(q33;p13), t(10;12)(q24;p13); in CML with translocation t(9;12)(q34;p13) |
| tumoral
|
| translocation
|
|
|
|
in ALL and in B cell precursor ALL with favorable outcome and translocations t(5;12)(q31-q33;p12), t(9;12) (p24;p13), t(12.21)(p13;q22) (see AML1), t(6;12)(q23;p13), (see STL) |
| tumoral
| fusion
| translocation
|
|
|
|
fused with FGFR3 in t(4;12) (p16;p13) in peripheral T-cell lymphoma |
| tumoral
| fusion
| translocation
|
|
|
|
fused with TTLM in t(12;13)(p13;q14) in lymphoblastic leukemia, with FRK in t(6;12) (q21;p13) in myelogenous leukemia |
| tumoral
|
| translocation
|
|
|
|
myelodysplasia and myeloproliferative disorders with translocation t(3;12)(q26;p13), t(1;12)(p36;p13), (1;12)(p13 or q31;p13) (14;12) (q11;p13) t(12;22) (p13;q11), t(12;15) (p13;q25), t(12;13)(p13-q12) |
| tumoral
|
| translocation
|
|
|
|
in acute myeloid leukemia (AML-M2) with translocation t(1;12) (q21;p13), t(7;12)(q36;p13) in myeloid malignancy with poor prognosis, in congenital fibrosarcoma (CFS), in congenital mesoblastic nephroma and in biphenotypic adult leukemia (BIPL) |
| tumoral
| fusion
|
|
|
|
|
ETV6/PTPRR in acute myelogenous leukemia with inv(12)(p13q13) |
| tumoral
| fusion
| translocation
|
|
|
|
ETV6/FLT3 (EF) fusion proteins in a patient with myeloproliferative disorder (MPD) and a t(12;13)(p13;q12) translocation (Vu 2009) |
| tumoral
| fusion
|
|
|
|
|
ETV6/GOT1 fusion in a case of t(10;12)(q24;p13)-positive myelodysplastic syndrome (Struski 2008) |
| tumoral
| somatic mutation
|
|
|
|
in early immature human T cell leukemias  |
| tumoral
| fusion
|
|
|
|
|
fusion of ETV6 and BAZ2A, in pre-B acute lymphoblastic leukaemia with a cryptic chromosome 12 rearrangement |
