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| Pbx1-deficient mice die at embryonic day 15/16 with severe hypoplasia or aplasia of multiple organs and widespread patterning defects of the axial and appendicular skeleton  | |
Pbx-dependent EMT programs mediate murine upper lip/primary palate morphogenesis and fusion via regulation of Snail1 |
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Pbx1-/- mouse embryos have pancreatic hypoplasia and marked defects in exocrine and endocrine cell differentiation prior to death at embryonic day (E) 15 or E16 |
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Pbx1+/- adult mice have pancreatic islet malformations, impaired glucose tolerance and hypoinsulinemia |
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Silencing of PBX1 by RNAi in MC3T3-E1 cells decreased the expression of Runx2 and Osterix, the critical transcription factors for osteogenesis, but accelerated cell proliferation and bone nodule formation |
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tissue-specific deletion of Pbx1 in mice corneal epithelium results in corneal dystrophy |